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Rho kinase (ROCK)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ROCK (17) Organoid (1) PKA (1) PKC (1) SGK (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (2) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (7)

17

Inhibitors & Agonists

1

Fluorescent Dye

1

Biochemical Assay Reagents

2

Recombinant Proteins

1

Antibodies

Targets Recommended: ROCK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

CAY10746	ROCK	Metabolic Disease
CAY10746 is a selective **Rho kinase (ROCK)** inhibitor. CAY10746 has inhibitory activity for ROCK I, ROCK II with IC₅₀ values of 0.014 μM and 0.003 μM, respectively. CAY10746 can be used for the research of diabetic retinopathy (DR) .

Rho-Kinase-IN-1	ROCK	Cancer
Rho-Kinase-IN-1 is a **Rho kinase (ROCK) inhibitor (K_i** values of 30.5 and 3.9 nM for ROCK1 and ROCK2, respectively) extracted from US20090325960A1, compound 1.008 .

Rho-Kinase-IN-2	ROCK	Neurological Disease
Rho-Kinase-IN-2 (Compound 23) is an orally active, selective, and central nervous system (CNS)-penetrant Rho Kinase (ROCK) inhibitor (ROCK2 IC₅₀=3 nM). Rho-Kinase-IN-2 can be used in Huntington’s research .

HY-148808

Zelasudil

RXC007
ROCK Others

Zelasudil is a Rho-associated (ROCK) kinase inhibitor. Zelasudil has a ROCK2 binding affinity .

Rho-Kinase-IN-3	ROCK	Neurological Disease
Rho-Kinase-IN-3 (compound 12) is a potent and selective **Rho kinase (ROCK1) inhibitor with an IC₅₀** value of 8 nM. Rho-Kinase-IN-3 can be used in research of hypertension .

SB-772077B dihydrochloride	ROCK	Cardiovascular Disease
SB-772077B dihydrochloride is an aminofurazan-based **Rho kinase (ROCK) inhibitor with IC₅₀*s of 5.6 nM and 6 nM toward ROCK1 and ROCK*2, respevtively .

HY-126913

Rhodblock 6

ROCK Cancer

Rhodblock 6 is a Rho kinase (ROCK) inhibitor that inhibits phospho-MRLC (myosin regulatory light chain) localization .

Y-27632 dihydrochloride 225+ Cited Publications	Organoid ROCK	Neurological Disease Cancer
Y-27632 dihydrochloride is an orally active and ATP-competitive *ROCK* (Rho-kinase) inhibitor (ROCK-I K_i=220 nM; ROCK-II K_i=300 nM). Y-27632 dihydrochloride shows antiepileptic effects .

Sovesudil PHP-201; AMA0076	ROCK	Others
Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting **Rho kinase (ROCK) inhibitor with IC₅₀*s of 3.7 and 2.3 nM for ROCK-I and ROCK*-II, respectively. Sovesudil lowers intraocular pressure (IOP) without inducing hyperemia .

Sovesudil hydrochloride PHP-201 hydrochloride; AMA0076 hydrochloride	ROCK	Neurological Disease
Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho kinase *(ROCK)* inhibitor with IC₅₀s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil hydrochloride lowers intraocular pressure (IOP) without inducing hyperemia .

Verosudil AR-12286	ROCK	Neurological Disease
Verosudil (AR-12286) is a potent, selective **Rho-kinase (ROCK) inhibitor with K_i*s of 2 and 2 nM for ROCK1 and ROCK*2, respectively. AR-12286 lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork .

PF-4950834	ROCK SGK PKA PKC	Inflammation/Immunology
PF-4950834 is a potent, selective, orally bioavailable, ATP-competitive **rho kinase inhibitor with IC₅₀** values of 8.35 nM and 33.12 nM against ROCK2 and ROCK1, respectively. PF-4950834 inhibits neutrophil migration .

ROCK2-IN-5	ROCK	Neurological Disease
ROCK2-IN-5 (compound 1d) is a hybrid compound containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids. ROCK2-IN-5 has good multitarget profile and good tolerability. ROCK2-IN-5 has the potential for thr research of Amyotrophic lateral sclerosis (ALS) with a SOD1 mutation .

GSK180736A 4 Publications Verification	ROCK	Cardiovascular Disease
GSK180736A is potent **Rho-associated coiled-coil kinase 1 (ROCK1) inhibitor with an IC₅₀ of 100 nM. GSK180736A is also a selective and ATP-competitive G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC₅₀** of 0.77 μM.

3-(4-Pyridyl)indole Rockout; 3-(4-Pyridinyl)-1H-indole; Rho kinase Inhibitor III, Rockout	ROCK	Inflammation/Immunology
3-(4-Pyridyl)indole (Rockout) is a **Rho-kinase (ROCK) inhibitor, with an IC₅₀** of 25 μM. 3-(4-Pyridyl)indole can inhibit blebbing and cause dissolution of actin stress fibers in a wound healing assay .

WF-536	ROCK	Cancer
WF-536 is an orally active inhibitor of **Rho-associated coiled-coil-containing protein kinase (ROCK)**. WF-536 has tumor anti-metastatic activity. WF-536 can be used for the research of cancer .

Y-27632 dihydrochloride	ROCK	Neurological Disease Cancer
Y-27632 dihydrochloride (GMP) is the GMP level of Y-27632 dihydrochloride (HY-10583). GMP guidelines are used to produce Y-27632 dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor with antiepileptic effect .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

	ROCK1 Protein, Human (Sf9) ROCK1; Rho-associated protein kinase 1; Renal carcinoma antigen NY-REN-35; Rho-associated; coiled-coil-containing protein kinase 1; Rho-associated; coiled-coil-containing protein kinase I; ROCK-I; p160 ROCK-1; p160ROCK	Human	Sf9 insect cells
	The ROCK1 protein is a key kinase that regulates the actin cytoskeleton, cell polarity, smooth muscle contraction, and multiple cellular functions. It controls stress fibers, focal adhesion formation, neurite retraction, and cell motility by phosphorylating substrates such as DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1, and PPP1R12A. ROCK1 Protein, Human (Sf9) is the recombinant human-derived ROCK1 protein, expressed by Sf9 insect cells , with tag free. The total length of ROCK1 Protein, Human (Sf9) is 410 a.a., .

	ROCK1 Protein, Human (Sf9, His) ROCK1; Rho-associated protein kinase 1; Renal carcinoma antigen NY-REN-35; Rho-associated; coiled-coil-containing protein kinase 1; Rho-associated; coiled-coil-containing protein kinase I; ROCK-I; p160 ROCK-1; p160ROCK	Human	Sf9 insect cells
	The ROCK1 protein is a key kinase that regulates the actin cytoskeleton, cell polarity, smooth muscle contraction, and multiple cellular functions. It controls stress fibers, focal adhesion formation, neurite retraction, and cell motility by phosphorylating substrates such as DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1, and PPP1R12A. ROCK1 Protein, Human (Sf9, His) is the recombinant human-derived ROCK1 protein, expressed by Sf9 insect cells , with N-8*His labeled tag. The total length of ROCK1 Protein, Human (Sf9, His) is 410 a.a., .

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